Tuesday, February 5, 2008

Reimer-Tiemann reaction - Phenols

Reimer-Tiemann reaction

When phenol is treated with choloroform and aqueous sodium hydroxide at 340 K followed by hydrolysis, an aldehydic group, -CHO group is introduced in the ring at a position ortho to the phenol group (OH group).

Ortho hydroxy benzaldehyde or salicylaldehyde is formed as the product of the reaction.

In addition, small amount of p-salicylaldehyde is also formed
In place of chloroform, carbon tetrachloride can be used. I this case o-salicylic acid is formed as the major product.

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